A double-blind study comparing two single-dose regimens of ketorolac with diclofenac in pain due to cancer.

STUDY OBJECTIVE

To compare the analgesic efficacy and safety of two single doses of ketorolac with diclofenac in acute cancer pain.

DESIGN

Double-blind, randomized, clinical study.

SETTING

Hospital-based clinical research center.

SUBJECTS

One hundred eighty patients suffering acute, moderate, or severe cancer pain.

INTERVENTIONS

A single intramuscular injection of ketorolac 10 or 30 mg or diclofenac 75 mg.

MEASUREMENTS AND MAIN RESULTS

Pain intensity was assessed 30 minutes and 1, 2, 3, 4, 5, and 6 hours after injection or until rescue drug administration. In approximately 70% of patients all treatments provided prompt sustained pain relief throughout the 6-hour observation period. There were no statistically significant differences in any of the analyzed efficacy measures among the three groups.

CONCLUSION

Intramuscular ketorolac 10 mg is adequate to relieve cancer pain, and is equivalent to ketorolac 30 mg and to diclofenac 75 mg.