Minotti V, Betti M, Ciccarese G, Fumi G, Tonato M, Del Favero A
Division of Medical Oncology, Perugia Hospital, Italy.
Pharmacotherapy. 1998 May-Jun;18(3):504-8.
To compare the analgesic efficacy and safety of two single doses of ketorolac with diclofenac in acute cancer pain.
Double-blind, randomized, clinical study.
Hospital-based clinical research center.
One hundred eighty patients suffering acute, moderate, or severe cancer pain.
A single intramuscular injection of ketorolac 10 or 30 mg or diclofenac 75 mg.
Pain intensity was assessed 30 minutes and 1, 2, 3, 4, 5, and 6 hours after injection or until rescue drug administration. In approximately 70% of patients all treatments provided prompt sustained pain relief throughout the 6-hour observation period. There were no statistically significant differences in any of the analyzed efficacy measures among the three groups.
Intramuscular ketorolac 10 mg is adequate to relieve cancer pain, and is equivalent to ketorolac 30 mg and to diclofenac 75 mg.
比较两种单剂量酮咯酸与双氯芬酸在急性癌痛中的镇痛疗效及安全性。
双盲、随机、临床研究。
医院临床研究中心。
180例患有急性、中度或重度癌痛的患者。
单次肌内注射10毫克或30毫克酮咯酸或75毫克双氯芬酸。
在注射后30分钟、1、2、3、4、5和6小时或直至给予解救药物时评估疼痛强度。在大约70%的患者中，所有治疗在6小时观察期内均能迅速持续缓解疼痛。三组之间在任何分析的疗效指标上均无统计学显著差异。
肌内注射10毫克酮咯酸足以缓解癌痛，且与30毫克酮咯酸和75毫克双氯芬酸等效。
