Grossman F
Department of Research, Friends Hospital, Philadelphia, Pennsylvania 19124-2399, USA.
Pharmacotherapy. 1998 May-Jun;18(3):600-6.
Agitation in the elderly, manifested by verbal and physical aggression, frequently results in increased morbidity and mortality for nursing home residents and reduced morale for the family and nursing home staff. It is also responsible for increased costs associated with caring for these residents. Pharmacologic interventions are often used but are frequently ineffective and associated with significant adverse effects. Few controlled studies of drug treatment are available, but divalproex sodium and carbamazepine are effective and well tolerated by this population. Divalproex sodium has advantages of fewer adverse side effects and drug-drug interactions.
老年人的激越表现为言语和身体攻击行为，这常常导致疗养院居民的发病率和死亡率增加，同时也会使患者家属及疗养院工作人员的士气低落。这还会导致照料这些居民的成本增加。药物干预措施经常被使用，但往往无效且伴有显著的不良反应。目前关于药物治疗的对照研究很少，但丙戊酸钠和卡马西平对这一人群有效且耐受性良好。丙戊酸钠具有副作用和药物相互作用较少的优点。
