Delafuente J C, Davis J A, Meuleman J R, Jones R A
Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville 32610-0486, USA.
Pharmacotherapy. 1998 May-Jun;18(3):631-6.
To determine if subcutaneous administration of influenza vaccine is as immunogenic as the intramuscular route, and to evaluate the frequency of local adverse events associated with both routes in elderly anticoagulated men.
Single-blind, prospective study of consecutively enrolled subjects.
Ambulatory clinic at a university-affiliated Veterans Affairs medical center.
Twenty-six men age 60 years or older, receiving therapeutic dosages of warfarin.
Subjects were randomized to receive either intramuscular or subcutaneous injection of a standard trivalent influenza vaccine.
Serum antibody titers to the vaccine's components were measured at baseline, and 6 weeks and 4 months after vaccination. Both routes of administration induced comparable serum antibody titers. There were no differences in adverse events at administration sites between routes of administration.
Elderly individuals are able to mount an immune response to influenza vaccine and produce antibody concentrations deemed protective. The routes of administration are similarly effective at inducing an immune response. The intramuscular route in anticoagulated elderly men does not commonly result in local bleeding complications.
确定皮下注射流感疫苗的免疫原性是否与肌肉注射途径相同，并评估老年抗凝男性中与这两种途径相关的局部不良事件的发生率。
对连续入选受试者进行的单盲前瞻性研究。
大学附属退伍军人事务医疗中心的门诊诊所。
26名年龄在60岁及以上、接受治疗剂量华法林治疗的男性。
受试者被随机分为接受肌肉注射或皮下注射标准三价流感疫苗。
在基线、接种疫苗后6周和4个月时测量针对疫苗成分的血清抗体滴度。两种给药途径诱导的血清抗体滴度相当。给药途径之间在给药部位的不良事件方面没有差异。
老年人能够对流感疫苗产生免疫反应并产生被认为具有保护作用的抗体浓度。给药途径在诱导免疫反应方面同样有效。抗凝老年男性的肌肉注射途径通常不会导致局部出血并发症。
