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腹主动脉瘤破裂修复术后的长期生存及晚期并发症

Long-term survival and late complications after repair of ruptured abdominal aortic aneurysms.

作者信息

Cho J S, Gloviczki P, Martelli E, Harmsen W S, Landis M E, Cherry K J, Bower T C, Hallett J W

机构信息

Division of Vascular Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA.

出版信息

J Vasc Surg. 1998 May;27(5):813-9; discussion 819-20. doi: 10.1016/s0741-5214(98)70260-5.

Abstract

PURPOSE

Long-term survival and late vascular complications in patients who survived repair of ruptured abdominal aortic aneurysms (RAAA) is not well known. The current study compared late outcome after repair of RAAA with those observed in patients who survived elective repair of abdominal aortic aneurysms (AAA).

METHODS

The records of 116 patients, 102 men and 14 women (mean age: 72.5 (8.3 years), who survived repair of RAAA (group I) between 1980 to 1989 were reviewed. Late vascular complications and survival were compared with an equal number of survivors of elective AAA repair matched for sex, age, surgeon, and date of operation (group II). Survival was also compared with the age and sex-matched white population of west-north central United States.

RESULTS

Late vascular complications occurred in 17% (20/116) of patients in group I and in 8% (9/116) in group II. Paraanastomotic aneurysms occurred more frequently in group I than in group II (17 vs. 8, p = 0.004). At follow-up, 32 patients (28%) were alive in group I (median survival: 9.4 years) and 53 patients (46%) were alive in group II (median survival: 8.7 years). Cumulative survival rates after successful RAAA repair at 1, 5, and 10 years were 86%, 64%, and 33%, respectively. These were significantly lower than survival rates at the same intervals after elective repair (97%, 74%, and 43%, respectively, p = 0.02) or survival of the general population (95%, 75%, and 52%, respectively, p < 0.001). Coronary artery disease was the most frequent cause of late death in both groups. Vascular and graft-related complications caused death in 3% (3/116) in group I and 1% (1/116) in group II. Cox proportional hazards modeling identified age (p = 0.0001), cerebrovascular disease (p = 0.009), and number of days on mechanical ventilation (p = 0.01) to be independent prognostic determinants of late survival in group I.

CONCLUSIONS

Late vascular complications after repair of RAAA were higher and late survival rates lower than after elective repair. These data support elective repair of AAA. As two-thirds of the patients discharged after repair of RAAA are alive at 5 years, aggressive management of RAAA remains justified.

摘要

目的

腹主动脉瘤破裂(RAAA)修复术后患者的长期生存情况及晚期血管并发症尚不明确。本研究比较了RAAA修复术后的晚期结局与择期腹主动脉瘤(AAA)修复术后患者的情况。

方法

回顾了1980年至1989年间116例RAAA修复术后存活患者(I组)的记录,其中男性102例,女性14例(平均年龄:72.5(8.3岁))。将晚期血管并发症和生存率与按性别、年龄、外科医生和手术日期匹配的同等数量的择期AAA修复术后存活患者(II组)进行比较。还将生存率与美国中西部北部年龄和性别匹配的白人人群进行比较。

结果

I组17%(20/116)的患者发生晚期血管并发症,II组为8%(9/116)。I组吻合口旁动脉瘤的发生率高于II组(17例对8例,p = 0.004)。随访时,I组32例患者(28%)存活(中位生存期:9.4年),II组53例患者(46%)存活(中位生存期:8.7年)。RAAA成功修复后1年、5年和10年的累积生存率分别为86%、64%和33%。这些显著低于择期修复后相同时间间隔的生存率(分别为97%、74%和43%,p = 0.02)或普通人群的生存率(分别为95%、75%和52%,p < 0.001)。冠状动脉疾病是两组晚期死亡的最常见原因。血管和移植物相关并发症导致I组3%(3/116)的患者死亡,II组1%(1/116)的患者死亡。Cox比例风险模型确定年龄(p = 0.0001)、脑血管疾病(p = 0.009)和机械通气天数(p = 0.01)是I组晚期生存的独立预后决定因素。

结论

RAAA修复术后的晚期血管并发症高于择期修复,晚期生存率低于择期修复。这些数据支持AAA的择期修复。由于RAAA修复术后出院的患者中有三分之二在5年后仍存活,因此对RAAA进行积极治疗仍然是合理的。

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