Boehncke W H, Pillekamp H, Gass S, Gall H
Department of Dermatology, University of Frankfurt, Germany.
Int J Dermatol. 1998 May;37(5):358-60. doi: 10.1046/j.1365-4362.1998.00337.x.
Protein contact dermatitis is a form of contact dermatitis possibly triggered by proteinaceous allergens.
We report two patients with a history of erythematous and urticarial skin reactions followed by transformation into prolonged papular symptoms upon contact with proteinaceous material.
The symptoms reported by the patients were reproducible by skin testing with meat (cow) and fish (salmon). Both patients experienced extracutaneous manifestations after ingestion of meat and fish, as proven by oral challenge. Specific immunoglobulin E (IgE) antibodies were detected in the patients' blood.
Both cases meet all major criteria of protein contact dermatitis, suggesting IgE-mediated immediate-type hypersensitivity with late-phase cutaneous reactions.
蛋白质接触性皮炎是接触性皮炎的一种形式，可能由蛋白质类变应原引发。
我们报告了两名患者，他们有红斑和荨麻疹皮肤反应病史，接触蛋白质类物质后转变为持续性丘疹症状。
通过用肉类（牛肉）和鱼类（三文鱼）进行皮肤试验，可重现患者报告的症状。经口服激发试验证实，两名患者在摄入肉类和鱼类后均出现皮肤外表现。在患者血液中检测到特异性免疫球蛋白E（IgE）抗体。
两例均符合蛋白质接触性皮炎的所有主要标准，提示为IgE介导的速发型超敏反应伴迟发性皮肤反应。
