99m锝-甲氧基异丁基异腈、99m锝-替曲膦和99m锝-Q12的体外和体内研究。
99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and in vivo.
作者信息
Bernard B F, Krenning E P, Breeman W A, Ensing G, Benjamins H, Bakker W H, Visser T J, de Jong M
机构信息
Department of Nuclear Medicine, University Hospital Dijkzigt and Erasmus University Medical School, Rotterdam, The Netherlands.
出版信息
Nucl Med Biol. 1998 Apr;25(3):233-40. doi: 10.1016/s0969-8051(97)00201-1.
The aim of this study was to compare uptake of 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and biodistribution in vivo in rats. In vitro, uptake decreased in the order MIBI-->tetrofosmin-->Q12. Uptake of MIBI and tetrofosmin, but not of Q12, in cultured tumor cells was dependent on the plasma membrane and mitochondrial potential. In vivo, heart uptake of all three compounds was high and stable. Tumor uptake decreased in the order MIBI-->Q12-->tetrofosmin and the tumor/blood ratio in the order MIBI-->tetrofosmin-->Q12.
本研究的目的是比较99mTc-MIBI、99mTc-替曲膦和99mTc-Q12在大鼠体内的体外摄取及生物分布。在体外，摄取量按MIBI>替曲膦>Q12的顺序降低。培养的肿瘤细胞中MIBI和替曲膦的摄取，但Q12的摄取不依赖于质膜和线粒体电位。在体内，所有三种化合物在心脏的摄取量都很高且稳定。肿瘤摄取量按MIBI>Q12>替曲膦的顺序降低，肿瘤/血液比值按MIBI>替曲膦>Q12的顺序降低。
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