Smad2转导来自受体丝氨酸 - 苏氨酸激酶和酪氨酸激酶的共同信号。
Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases.
作者信息
de Caestecker M P, Parks W T, Frank C J, Castagnino P, Bottaro D P, Roberts A B, Lechleider R J
机构信息
Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892-5055 USA.
出版信息
Genes Dev. 1998 Jun 1;12(11):1587-92. doi: 10.1101/gad.12.11.1587.
Abstract
SMAD proteins mediate signals from receptor serine-threonine kinases (RSKs) of the TGF-beta superfamily. We demonstrate here that HGF and EGF, which signal through RTKs, can also mediate SMAD-dependent reporter gene activation and induce rapid phosphorylation of endogenous SMAD proteins by kinase(s) downstream of MEK1. HGF induces phosphorylation and nuclear translocation of epitope-tagged Smad2 and a mutation that blocks TGF-beta signaling also blocks HGF signal transduction. Smad2 may thus act as a common positive effector of TGF-beta- and HGF-induced signals and serve to modulate cross talk between RTK and RSK signaling pathways.
摘要
SMAD蛋白介导来自转化生长因子-β（TGF-β）超家族受体丝氨酸 - 苏氨酸激酶（RSK）的信号。我们在此证明，通过受体酪氨酸激酶（RTK）发出信号的肝细胞生长因子（HGF）和表皮生长因子（EGF），也可介导依赖SMAD的报告基因激活，并通过MEK1下游的激酶诱导内源性SMAD蛋白的快速磷酸化。HGF诱导表位标记的Smad2的磷酸化和核转位，并且阻断TGF-β信号传导的突变也阻断HGF信号转导。因此，Smad2可能作为TGF-β和HGF诱导信号的共同正向效应物，并用于调节RTK和RSK信号通路之间的串扰。
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本文引用的文献
1
TGF-beta signalling from cell membrane to nucleus through SMAD proteins.转化生长因子-β（TGF-β）通过SMAD蛋白从细胞膜向细胞核传递信号。
Nature. 1997 Dec 4;390(6659):465-71. doi: 10.1038/37284.
2
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.Smad4/DPC4肿瘤抑制因子在转化生长因子β诱导的转录复合物中的双重作用
Genes Dev. 1997 Dec 1;11(23):3157-67. doi: 10.1101/gad.11.23.3157.
3
Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.肿瘤抑制因子Smad4是一种转化生长因子β诱导型DNA结合蛋白。
Mol Cell Biol. 1997 Dec;17(12):7019-28. doi: 10.1128/MCB.17.12.7019.
4
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.Smad2 C末端的丝氨酸465和丝氨酸467磷酸化介导与Smad4的相互作用，是转化生长因子-β信号传导所必需的。
J Biol Chem. 1997 Oct 31;272(44):28107-15. doi: 10.1074/jbc.272.44.28107.
5
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.Smad2-Smad4复合物形成及信号传导需要TbetaRI将Smad2的丝氨酸465和丝氨酸467磷酸化。
J Biol Chem. 1997 Oct 31;272(44):27678-85. doi: 10.1074/jbc.272.44.27678.
6
Specificity in protein-tyrosine kinase signaling.
Adv Second Messenger Phosphoprotein Res. 1997;31:41-8. doi: 10.1016/s1040-7952(97)80007-9.
7
Synergistic interactions between bFGF and a TGF-beta family member may mediate myogenic signals from the neural tube.碱性成纤维细胞生长因子（bFGF）与转化生长因子-β（TGF-β）家族成员之间的协同相互作用可能介导来自神经管的生肌信号。
Development. 1997 Sep;124(18):3511-23. doi: 10.1242/dev.124.18.3511.
8
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Nature. 1997 Oct 9;389(6651):618-22. doi: 10.1038/39348.
9
Smad4 and FAST-1 in the assembly of activin-responsive factor.Smad4与FAST-1在激活素反应因子组装中的作用
Nature. 1997 Sep 4;389(6646):85-9. doi: 10.1038/38008.
10
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic.果蝇Mad蛋白与DNA结合，并直接介导由Decapentaplegic蛋白对残翅基因的激活作用。
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