Lee A G, Sforza P D, Fard A K, Repka M X, Baskin D S, Dauser R C
Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.
J Neuroophthalmol. 1998 Jun;18(2):102-5.
Pituitary adenoma is an uncommon intracranial tumor of children. The authors retrospectively reviewed the records of 10 patients younger than 17 years of age with pituitary adenoma. Five patients had visual loss at presentation. Four of these five patients with visual loss and extrasellar tumor extension were adolescents (12-15 years of age). Seven of 10 patients underwent neurosurgery. Of the five patients with visual loss, three patients experienced visual improvement, one patient was unchanged, and one patient did not have follow-up. The visual loss in these patients tended to be more severe and more likely to be associated with optic atrophy than adult patients. Although they are relatively uncommon, ophthalmologists should be aware that pituitary adenomas may occur in children and that these tumors when present in the pubertal period may be more likely to exhibit extrasellar extension or invasiveness.
垂体腺瘤是一种儿童期少见的颅内肿瘤。作者回顾性分析了10例17岁以下垂体腺瘤患儿的病历。5例患儿初诊时存在视力丧失。这5例视力丧失且肿瘤向鞍外扩展的患儿中有4例为青少年(12 - 15岁)。10例患儿中有7例接受了神经外科手术。在5例视力丧失的患儿中,3例视力改善,1例无变化,1例未进行随访。与成年患者相比,这些患儿的视力丧失往往更严重,且更易伴有视神经萎缩。尽管垂体腺瘤在儿童中相对少见,但眼科医生应意识到儿童也可能发生垂体腺瘤,且这些肿瘤在青春期出现时可能更易发生鞍外扩展或侵袭。