Naganuma R, Tsuchida H, Okanuma M, Iwasaki H, Namiki A
Department of Anesthesiology, Sapporo Medical University School of Medicine.
Masui. 1998 May;47(5):562-5.
We investigated the efficacy and untoward effects of low doses of propofol for intrathecal morphine-induced pruritus. Twenty gynecological and obstetric surgical patients received spinal anesthesia with 0.5% tetracaine and phenylephrine, as well as 0.2 mg morphine. Seven of them (35%) complained pruritus graded according to the treatment necessary in the postoperative period. Propofol, 10 mg or 20 mg, successfully alleviated the pruritus in 6 patients out of 7. Further treatment was not necessary in 5 of them. One patient was resistant to treatments by 20 mg of propofol and 0.1 mg of naloxone. Three patients transiently fell in sleep even after administering 10 mg of propofol. The authors conclude that low dose propofol is effective in treating intrathecal morphine-induced pruritus, although it may transiently causes hypnosis in postoperative patients.
我们研究了低剂量丙泊酚治疗鞘内注射吗啡所致瘙痒的疗效及不良反应。20例妇产科手术患者接受了0.5%丁卡因和去氧肾上腺素以及0.2mg吗啡的脊髓麻醉。其中7例（35%）术后出现瘙痒，根据治疗需求进行分级。10mg或20mg丙泊酚成功缓解了7例患者中6例的瘙痒。其中5例无需进一步治疗。1例患者对20mg丙泊酚和0.1mg纳洛酮治疗无效。3例患者即使注射10mg丙泊酚后也出现了短暂睡眠。作者得出结论，低剂量丙泊酚治疗鞘内注射吗啡所致瘙痒有效，尽管可能会使术后患者短暂催眠。
