Beier-Holgersen R, Boesby S
Kirurgisk gastroenterologisk afdeling D2, Amtssygehuset i Glostrup.
Ugeskr Laeger. 1998 May 25;160(22):3223-6.
We undertook this study to test the hypothesis that early enteral nutrition might reduce the incidence of serious complications after major abdominal surgery. In a randomized double blind prospective trial 30 patients received Nutridrink and 30 patients received placebo through a nasoduodenal feeding tube. On the day of operation the patients were given median 600 ml nutrition/placebo, 60 ml/h. On the first postoperative day the patients received median 1000 ml nutrition/placebo, second day median 1200 ml nutrition, 1400 ml placebo, third postoperative day median 1000 ml nutrition, 1150 ml placebo and 4th postoperative day median 1000 ml nutrition, 800 ml placebo. All patients were followed for 30 days by the same investigator. The two groups were not different with regard to nutritional status and type of operation. The rate of postoperative infectious complications was significantly lower in the nutrition group, 2/30 compared to 14/30 in the placebo group (p = 0.0009). We conclude that early enteral nutrition given to patients after major abdominal surgery is followed by a major reduction in infectious complications.
我们进行这项研究以检验早期肠内营养可能降低腹部大手术后严重并发症发生率这一假设。在一项随机双盲前瞻性试验中，30例患者通过鼻十二指肠喂养管接受Nutridrink，30例患者接受安慰剂。手术当天，患者接受的营养物/安慰剂中位数为600毫升，60毫升/小时。术后第一天，患者接受的营养物/安慰剂中位数为1000毫升，第二天营养物中位数为1200毫升，安慰剂为1400毫升，术后第三天营养物中位数为1000毫升，安慰剂为1150毫升，术后第四天营养物中位数为1000毫升，安慰剂为800毫升。所有患者均由同一位研究者随访30天。两组在营养状况和手术类型方面无差异。营养组术后感染性并发症发生率显著低于安慰剂组，分别为2/30和14/30（p = 0.0009）。我们得出结论，腹部大手术后给予患者早期肠内营养可使感染性并发症大幅减少。
