Kiyokawa E, Mochizuki N, Kurata T, Matsuda M
Department of Pathology, National Institute of Infectious Diseases, International Medical Center of Japan, Tokyo.
Crit Rev Oncog. 1997;8(4):329-42. doi: 10.1615/critrevoncog.v8.i4.30.
v-Crk is a member of the family of adaptor-type signaling molecules that consist mostly of SH2 and SH3 domains. The cellular homologs of v-Crk includes CrkI, CrkII, and CrkL; these have been isolated from species ranging from lower vertebrates to man. Crk-family proteins are involved in a variety of signaling cascades such as those of growth factor receptor, integrin, T-cell receptor, B-cell antigen receptor, and cytokines. It has been postulated that the primary function of Crk is to recruit cytoplasmic proteins in the vicinity of tyrosine kinases through SH2-phosphotyrosine interaction. Thus, the output from Crk depends on the SH3-binding proteins, which include the C3G guanine nucleotide exchange protein for Rap1, Abl tyrosine kinase, DOCK180, and the Sos guanine nucleotide exchange protein for Ras. The variety of the Crk-binding proteins indicate the pleiotropic function of Crk.
v-Crk是衔接子型信号分子家族的成员，该家族主要由SH2和SH3结构域组成。v-Crk的细胞同源物包括CrkI、CrkII和CrkL；这些已从低等脊椎动物到人类等物种中分离出来。Crk家族蛋白参与多种信号级联反应，如生长因子受体、整合素、T细胞受体、B细胞抗原受体和细胞因子的信号级联反应。据推测，Crk的主要功能是通过SH2-磷酸酪氨酸相互作用在酪氨酸激酶附近募集细胞质蛋白。因此，Crk的输出取决于SH3结合蛋白，其中包括用于Rap1的C3G鸟嘌呤核苷酸交换蛋白、Abl酪氨酸激酶、DOCK180以及用于Ras的Sos鸟嘌呤核苷酸交换蛋白。多种Crk结合蛋白表明了Crk的多效性功能。
