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衰老对大鼠纹状体前脑啡肽原和前速激肽原mRNA含量对慢性氟哌啶醇治疗反应的影响：采用溶液杂交核糖核酸酶保护分析法进行测定

The effect of aging on the response of striatal preproenkephalin and preprotachykinin mRNA contents to chronic haloperidol treatment in rats: measurement by solution-hybridization RNase protection assay.

作者信息

Lau S M, Tang F

机构信息

Department of Physiology, Faculty of Medicine, The University of Hong Kong, China.

出版信息

Neurosci Lett. 1998 Apr 17;246(1):33-6. doi: 10.1016/s0304-3940(98)00202-x.

DOI:10.1016/s0304-3940(98)00202-x
PMID:9622201
Abstract

The preproenkephalin (PPeK) and preprotachykinin (PPT) mRNA contents in 3-, 10- and 23-month-old rats in the striatum were measured by solution hybridization-RNase protection assay after 3 weeks of haloperidol injection. Haloperidol increased striatal PPek mRNA. There was no age-related difference in the response of striatal PPeK mRNA to chronic haloperidol treatment. The PPT mRNA decreased by 21% after the haloperidol treatment in young rats only. Meanwhile, age decreased the PPT mRNA by 27 and 24% in 10- and 23-month-old rats, respectively. It is concluded that there is a difference in the effects of aging on the response of PPek and PPT mRNA contents to haloperidol and that the loss of PPT mRNA response in 10- and 23-month-old rats might be due to the change of dopamine system of the striatum in these rats.

摘要

通过溶液杂交 - 核糖核酸酶保护分析法，测量了经氟哌啶醇注射3周后3月龄、10月龄和23月龄大鼠纹状体中前脑啡肽原（PPeK）和前速激肽原（PPT）的mRNA含量。氟哌啶醇增加了纹状体PPek mRNA的含量。纹状体PPeK mRNA对慢性氟哌啶醇治疗的反应不存在与年龄相关的差异。仅在幼鼠中，氟哌啶醇治疗后PPT mRNA降低了21%。同时，在10月龄和23月龄大鼠中，年龄分别使PPT mRNA降低了27%和24%。结论是，衰老对PPek和PPT mRNA含量对氟哌啶醇反应的影响存在差异，并且10月龄和23月龄大鼠中PPT mRNA反应的丧失可能归因于这些大鼠纹状体多巴胺系统的变化。

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