慢性氟哌啶醇治疗可降低垂体前叶中前脑啡肽原mRNA水平：一项采用溶液杂交-核糖核酸酶保护分析的研究
Chronic haloperidol treatment decreases preproenkephalin mRNA in the anterior pituitary: a study by solution-hybridization-RNase protection assay.
作者信息
Tang F, Lau S M
机构信息
Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong.
出版信息
Neurosci Lett. 1996 Dec 27;221(1):66-8. doi: 10.1016/s0304-3940(96)13274-2.
PMID:9014182
Abstract
By solution-hybridization-RNase protection assay, the preproenkephalin (PPek) mRNA in the anterior pituitary (AL) of male rats was found to decrease by 42% after 3 weeks haloperidol treatment. It is concluded that dopamine may stimulate the AL enkephalinergic system at the level of gene expression.
摘要
通过溶液杂交-RNase保护试验发现，给予雄性大鼠氟哌啶醇3周后，其垂体前叶（AL）中前脑啡肽原（PPek）mRNA减少了42%。由此得出结论，多巴胺可能在基因表达水平刺激垂体前叶脑啡肽能系统。
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