Katai M, Sakurai A, Itakura Y, Ikeo Y, Nakajima K, Hara M, Iijima S, Kaneko T, Kobayashi M, Ichikawa K, Aizawa T, Hashizume K
Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto, Japan.
Endocr J. 1997 Dec;44(6):841-5. doi: 10.1507/endocrj.44.841.
Multiple endocrine neoplasia type 1 (MEN 1) is rarely reported in Japanese and other oriental populations. To examine if there is a racial difference in the prevalence of MEN 1, we initiated extensive work on patients with endocrine tumors for additional lesions, and annual screening of family members of affected patients. In a four-year study, eleven asymptomatic patients were found by family screening, and the number of patients with MEN 1 in our clinics increased from 16 to 38. Estimated prevalence of MEN 1 was no less than 0.018/1000. MEN 1 may not be as rare as had been thought in Japanese, and the prevalence of MEN 1 in Japanese would not be significantly different from that of Caucasians. Systemic surveillance and extensive screening of family members are required for early detection and management of patients.
1型多发性内分泌腺瘤病（MEN 1）在日本人和其他东方人群中鲜有报道。为了研究MEN 1的患病率是否存在种族差异，我们对内分泌肿瘤患者展开了广泛研究以寻找其他病变，并对患病患者的家庭成员进行年度筛查。在一项为期四年的研究中，通过家族筛查发现了11例无症状患者，我们诊所中MEN 1患者的数量从16例增加到了38例。MEN 1的估计患病率不少于0.018/1000。MEN 1在日本人中可能并不像之前认为的那么罕见，其在日本人中的患病率与白种人相比并无显著差异。为了早期发现和治疗患者，需要进行系统监测并对家庭成员进行广泛筛查。
