Wilkinson S, Young M, Shepherd J J
Department of Surgery, University of Tasmania, Hobart, Australia.
Aust N Z J Surg. 1996 Mar;66(3):141-3. doi: 10.1111/j.1445-2197.1996.tb01142.x.
An extensive programme was undertaken to trace and screen four known families in Tasmania with multiple endocrine neoplasia type 1 (MEN-1).
Written and personal contact was made with family members over the age of 20 years recommending a review by family practitioners for the purpose of recording their medical history and collecting a blood sample. Those suspected of MEN-1 were referred to our Department for further investigation.
In January 1993, the total number of individuals alive and known to be affected by MEN-1 was 107, giving a prevalence of MEN-1 disease in Tasmania of 23/100 000. The estimated prevalence of MEN-1 trait in Tasmania (including affected cases and those considered at 50% risk of possessing the trait) is 45/100 000.
The prevalence of MEN-1 has never previously been determined accurately. The prevalence of MEN-1 in Tasmania is at the upper end of the possible range and would justify the allocation of resources for screening programmes equal to those available for the detection of several less prevalent genetic diseases.
开展了一项广泛的项目，对塔斯马尼亚州四个已知的多发性内分泌腺瘤1型（MEN - 1）家族进行追踪和筛查。
与20岁以上的家庭成员进行书面和个人联系，建议家庭医生进行复查，以记录他们的病史并采集血样。那些疑似患有MEN - 1的患者被转介到我们科室进行进一步调查。
1993年1月，已知存活且受MEN - 1影响的个体总数为107人，塔斯马尼亚州MEN - 1疾病的患病率为23/100000。塔斯马尼亚州MEN - 1特征的估计患病率（包括患病病例和被认为有50%携带该特征风险的个体）为45/100000。
此前从未准确确定过MEN - 1的患病率。塔斯马尼亚州MEN - 1的患病率处于可能范围的上限，这为筛查项目分配资源提供了依据，其资源分配应等同于用于检测几种不太常见遗传病的资源。
