Hinchcliff K W, McKeever K H
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210-1089, USA.
Equine Vet J. 1998 May;30(3):246-50. doi: 10.1111/j.2042-3306.1998.tb04495.x.
The effect of blood volume repletion after frusemide administration on the right atrial and pulmonary artery pressure responses of horses to exercise has not been reported. We examined right atrial and pulmonary artery pressure and plasma atrial natriuretic peptide concentration (ANP) responses to an incremental exercise test in 6 Standardbred mares. Horses were treated, in a 3 way cross over design, with isotonic saline, frusemide (1 mg/kg bwt, i.v.), and frusemide followed 3 h later by lactated Ringer's solution (12 ml/kg bwt, i.v.). Three and a half hours after saline or frusemide administration the horses completed a standard exercise test. Frusemide significantly affected the right atrial and pulmonary artery pressure and ANP responses to exercise. Fluid administration decreased plasma total protein concentrations at rest and during running and abolished the effects of frusemide on the haemodynamic and ANP responses to exercise. These results suggest that the haemodynamic effect of frusemide in running horses is mediated, in large part, by a reduction in plasma and blood volume.
速尿给药后补充血容量对马匹运动时右心房和肺动脉压力反应的影响尚未见报道。我们检测了6匹标准赛马母马在递增运动试验中右心房和肺动脉压力以及血浆心房利钠肽浓度（ANP）的反应。采用三交叉设计，对马匹分别静脉注射等渗盐水、速尿（1mg/kg体重），3小时后再静脉注射乳酸林格氏液（12ml/kg体重）。在给予盐水或速尿3.5小时后，马匹完成标准运动试验。速尿显著影响右心房和肺动脉压力以及运动时的ANP反应。补液降低了静息和跑步时的血浆总蛋白浓度，并消除了速尿对运动时血流动力学和ANP反应的影响。这些结果表明，速尿对奔跑马匹的血流动力学作用在很大程度上是由血浆和血容量减少介导的。
