沙鼠海马缺血期间体温过低的程度与缺血后DNA片段化预防效果之间的关系。
Relationship between magnitude of hypothermia during ischemia and preventive effect against post-ischemic DNA fragmentation in the gerbil hippocampus.
作者信息
Niwa M, Hara A, Iwai T, Nakashima M, Yano H, Yoshimi N, Mori H, Uematsu T
机构信息
Department of Pharmacology, Gifu University School of Medicine, Gifu 500-8705, Japan.
出版信息
Brain Res. 1998 Jun 1;794(2):338-42. doi: 10.1016/s0006-8993(98)00324-2.
Protective effect of hypothermia against DNA fragmentation in hippocampal CA1 field after transient forebrain ischemia in gerbils was evaluated by changing the magnitude of hypothermia. Inhibition of DNA fragmentation was proportional to the magnitude of hypothermia. The result indicates that, in terms of susceptibility to ischemia, hippocampal CA1 neurons are sensitive to a relatively small decrement of temperature, with temperatures </=35 degreesC being critical for the prevention of apoptotic process following transient forebrain ischemia.
通过改变低温的程度，评估了低温对沙土鼠短暂性前脑缺血后海马CA1区DNA片段化的保护作用。DNA片段化的抑制与低温程度成正比。结果表明，就对缺血的易感性而言，海马CA1神经元对相对较小的温度降低敏感，温度≤35℃对于预防短暂性前脑缺血后的凋亡过程至关重要。
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