Guzmán Martínez-Valls P L, Ferrero Doria R, Morga Egea J P, Navas Pastor J, Tomás Ros M, Rico Galiano J L, Sempere Gutiérrez A, Fontana Compiano L O
Servicio de Urología, Hospital General Universitario de Murcia, España.
Arch Esp Urol. 1998 Apr;51(3):254-6.
To analyze the incidence of non-urothelial neoplasms in patients with infiltrating bladder tumor submitted to radical surgery.
A retrospective study was conducted in patients who underwent radical cystoprostatectomy for an infiltrating bladder tumor from 1987-1996. The pathological and follow-up data were analyzed.
Of 120 patients submitted to radical cystoprostatectomy for an infiltrating bladder tumor, 23 (19%) had an associated non-urothelial neoplasm: 14 (61%) were metachronous and 9 (39%) were synchronous. Two patients had two secondary tumors (9%).
We have found a high incidence of non-urothelial tumor in patients with infiltrating bladder tumor. By order of frequency, these were prostate cancer, gastrointestinal cancer, pulmonary cancer, etc. Studies have ascribed the association of prostate and bladder cancer to the deletion of suppressor genes.
分析接受根治性手术的浸润性膀胱肿瘤患者中非尿路上皮肿瘤的发生率。
对1987年至1996年间因浸润性膀胱肿瘤接受根治性膀胱前列腺切除术的患者进行回顾性研究。分析病理和随访数据。
在120例因浸润性膀胱肿瘤接受根治性膀胱前列腺切除术的患者中，23例（19%）伴有非尿路上皮肿瘤：14例（61%）为异时性，9例（39%）为同时性。2例患者有两种继发性肿瘤（9%）。
我们发现浸润性膀胱肿瘤患者中非尿路上皮肿瘤的发生率较高。按发生频率依次为前列腺癌、胃肠道癌、肺癌等。研究将前列腺癌和膀胱癌的关联归因于抑癌基因的缺失。
