Angulo J C, Hontoria J, Dehaini A, Guil M, Sánchez-Chapado M
Servicio de Urología, Hospital Príncipe de Asturias, Universidad de Alcalá de Henares, Madrid.
Actas Urol Esp. 1996 Sep;20(8):720-4.
Presentation of a case-control study on 755 subjects with the purpose of defining whether the development of a neoplasia on any organ and of any histological type, either synchronous or metachronous, occurs more frequently in patients who already have vesical carcinoma (338 cases) versus other populations of similar epidemiological characteristics comprising subjects who do not present that condition (417 controls). The evaluation of the difference between both groups establishes a cause-effect relationship expressed in terms of an odds ratio of 2:11 which allows to claim that presence of a second neoplasia is more frequent in patients with vesical carcinoma (p < 0.001). The paper also includes a discussion on the distribution to organs and systems. Once the cases with urothelial site (renal pelvis, ureter or urethra) are excluded, prostate adenocarcinoma is the most frequent form associated to vesical carcinoma, followed at a distance by renal adenocarcinoma, epidermoid carcinoma of the larynx and bronchopulmonary carcinoma. Cumulative incidence of secondary neoplasias, including tumours diagnosed synchronically is 12% at 54 months.
一项针对755名受试者的病例对照研究，目的是确定在患有膀胱癌的患者（338例）与其他具有相似流行病学特征但未患膀胱癌的人群（417例对照）中，任何器官、任何组织学类型的肿瘤（无论是同时性还是异时性）的发生频率是否更高。对两组之间差异的评估建立了一种因果关系，用优势比2:11表示，这表明膀胱癌患者中出现第二种肿瘤的频率更高（p < 0.001）。该论文还包括对肿瘤在器官和系统中的分布的讨论。排除尿路上皮部位（肾盂、输尿管或尿道）的病例后，前列腺腺癌是与膀胱癌相关的最常见形式，其次是肾腺癌、喉表皮样癌和支气管肺癌。包括同步诊断的肿瘤在内，继发性肿瘤的累积发病率在54个月时为12%。
