Paulmyer-Lacroix O, Mollé L, Noizet A, Guérin A, Mollar M, Gamerre M, Grillo J M
CHU La Conception, Centre de procréation médicalement assistée, Marseille.
Contracept Fertil Sex. 1998 Apr;26(4):300-6.
We analyzed retrospectively 936 intrauterine insemination (IUI) cycles with husband's sperm (384 couples). Superovulation and induction monitoring occurred in the majority of cases; IUI was timed 36-40 h after ovulatory hCG. The overall pregnancy rate per cycle (PR/C) was 11.4% (107/936). Data analysis demonstrated that PR/C decreased with infertility duration, woman's age (especially after 38 years old) and number of attempts (significantly after the 4 th cycle). Superovulation (in particular by antiestrogens) and induction monitoring seemed to provide an increase in cycle pregnancy rate. Highest PR/C were observed in dysovulation and male infertility groups. In cases of sperm defects, our data showed that 2 parameters had a significant influence on pregnancy outcome: the number of motile progressive inseminated spermatozoa (> 300,000) and the spermatozoa survival rate after 24 h (> 50%). As a conclusion, intrauterine insemination can be proposed as a satisfying treatment of infertility, if precise protocol is followed and its indications well-defined.
我们回顾性分析了936个使用丈夫精子的宫腔内人工授精（IUI）周期（384对夫妇）。大多数病例进行了超排卵和诱导监测；IUI在排卵后注射人绒毛膜促性腺激素（hCG）36 - 40小时后进行。每个周期的总体妊娠率（PR/C）为11.4%（107/936）。数据分析表明，PR/C随着不孕持续时间、女性年龄（尤其是38岁以后）和尝试次数（第4个周期后显著下降）而降低。超排卵（特别是通过抗雌激素）和诱导监测似乎能提高周期妊娠率。在排卵障碍和男性不育组中观察到最高的PR/C。在精子缺陷的病例中，我们的数据表明有两个参数对妊娠结局有显著影响：活动前进的授精精子数量（>300,000）和24小时后的精子存活率（>50%）。结论是，如果遵循精确的方案并明确其适应症，宫腔内人工授精可作为一种令人满意的不孕治疗方法。
