Veth R P, van der Eijken J W, Taminiau A H
Academisch Ziekenhuis, afd. Orthopedie, Nijmegen.
Ned Tijdschr Geneeskd. 1998 May 2;142(18):1004-9.
In the fifties, patients with a malignant bone tumour were treated with radiotherapy, sometimes supplemented by resection, as recommended by the Bone Tumour Committee established in 1953. In the seventies, improvement of imaging techniques and chemotherapy made limb-saving surgery possible. Currently, 70% of patients with a malignant tumour of the locomotor apparatus are treated by limb saving, oncologically justified surgery. The surgical defects can be repaired with the aid of an endoprosthesis, or bone homografting or autografting. Children are often treated with an operation involving 180% rotation of the ankle to function as the knee, combined with a prosthesis. Adults are sometimes treated with this technique, but also with internal ('standard') prostheses and donor bone. The future will have to make clear which technique is to be preferred in which situation. Probably, typing and prognosis of various tumours may improve, leading to better insight into the treatment. Centralization of the treatment of rare tumours may also contribute to improvement of the treatment and its scientific research.
在五十年代,恶性骨肿瘤患者接受放射治疗,有时根据1953年成立的骨肿瘤委员会的建议辅以切除术。在七十年代,成像技术和化疗的进步使保肢手术成为可能。目前,70%的运动器官恶性肿瘤患者接受保肢、肿瘤学上合理的手术治疗。手术缺损可借助内置假体、同种异体骨移植或自体骨移植进行修复。儿童常采用将踝关节旋转180度以替代膝关节功能并结合假体的手术进行治疗。成人有时也采用这种技术,但也会使用内置(“标准”)假体和供体骨。未来必须明确在何种情况下哪种技术更可取。各种肿瘤的分型和预后可能会改善,从而对治疗有更深入的了解。罕见肿瘤治疗的集中化也可能有助于治疗及其科研的改进。