Seki K, Kobayashi K, Tomiya Y, Sakurada J, Murai M, Usui A, Masuda S
Department of Microbiology, The Jikei University School of Medicine, Tokyo, Japan.
Microbiol Immunol. 1998;42(4):321-4. doi: 10.1111/j.1348-0421.1998.tb02289.x.
A bacterial strain with affinity to Candida albicans was successfully obtained from a natural environment. An uncovered Petri dish containing a suspension of heat-killed C. albicans cells was allowed to stand in a laboratory for several days. Some bacteria which had adhered to the candidal cells were tested for their ability to agglutinate the cells. A bacterial strain, designated later as CAB-1, was found to agglutinate candidal cells through bridging by mannose-sensitive pili. CAB-1 showed similar bacteriological characteristics to those of Citrobacter freundii by ID test. The adherence of CAB-1 to candidal cell was precisely presented by scanning electron microscopy. The inhibitory effect of CAB-1 attachment to candidal cells on the growth of Candida was also preliminarily confirmed.
从自然环境中成功获得了一株对白色念珠菌具有亲和力的细菌菌株。将一个装有热灭活白色念珠菌细胞悬液的未加盖培养皿在实验室放置数天。对一些粘附在念珠菌细胞上的细菌进行了凝集细胞能力的测试。发现一株后来命名为CAB - 1的细菌菌株通过甘露糖敏感菌毛形成桥联来凝集念珠菌细胞。通过鉴定试验，CAB - 1显示出与弗氏柠檬酸杆菌相似的细菌学特征。通过扫描电子显微镜精确呈现了CAB - 1对念珠菌细胞的粘附情况。还初步证实了CAB - 1附着于念珠菌细胞对念珠菌生长的抑制作用。
