Nishikawa S, Hirasue M, Miura T, Yamada K, Sasaki S, Nakane A
Department of Bacteriology, Hirosaki University School of Medicine, Aomori, Japan.
Microbiol Immunol. 1998;42(4):325-7. doi: 10.1111/j.1348-0421.1998.tb02290.x.
Orally ingested Listeria monocytogenes is known to penetrate into Peyer's patches (PP) and translocate to the spleen and liver. Herein, extraintestinal dissemination of the bacterium independent of PP was investigated. Dissemination of Listeriae to the spleen and liver was observed in intrarectally infected mice as well as in intragastrically infected animals in spite that no Listeriae were detected in the small intestines of mice infected intrarectally. Decreased numbers of intestinal intraepithelial lymphocytes (iIEL) and increased numbers of lymphocytes in the contents of the small and large intestines were observed after intragastric infection and in the large intestine after intrarectal infection, giving the assumption that the leakage of iIEL caused by injury of epithelial layers in intestines might occur during infection. These results suggest that L. monocytogenes might be able to disseminate through small and large intestines in part by a PP-independent mechanism.
已知经口摄入的单核细胞增生李斯特菌可穿透派尔集合淋巴结（PP）并转移至脾脏和肝脏。在此，对该细菌不依赖PP的肠外播散进行了研究。在经直肠感染的小鼠以及经胃感染的动物中均观察到李斯特菌向脾脏和肝脏的播散，尽管在经直肠感染的小鼠小肠中未检测到李斯特菌。经胃感染后，观察到小肠和大肠内容物中肠上皮内淋巴细胞（iIEL）数量减少，淋巴细胞数量增加；经直肠感染后，在大肠中也观察到类似情况，这表明在感染过程中，肠道上皮层损伤可能导致iIEL渗漏。这些结果表明，单核细胞增生李斯特菌可能部分通过不依赖PP的机制在小肠和大肠中播散。
