Shen H M, Peters A, Baron B, Zhu X, Storb U
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60617, USA.
Science. 1998 Jun 12;280(5370):1750-2. doi: 10.1126/science.280.5370.1750.
Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.
免疫球蛋白（Ig）基因在作为记忆B细胞前体的B淋巴细胞中发生高度突变。这些突变与转录起始相关，但非Ig启动子在突变过程中也是允许的；因此，在发生突变的B细胞中表达的其他基因也可能发生体细胞超突变。在c-MYC、S14或甲胎蛋白（AFP）基因中未观察到显著突变，但在正常个体的大部分记忆B细胞中，BCL-6发生了高度突变。突变模式与Ig基因相似。
