Andrew G, Chan G, Schiff D
J Pediatr. 1978 Jun;92(6):995-7. doi: 10.1016/s0022-3476(78)80385-0.
The ketogenic potential of Intralipid was studied in two groups of infants: 12 were SGA and 15 AGA; all were clinically stable and less than 48 hours of age. During four-hour Intralipid tolerance tests, the SGA infants achieved significantly higher plasma TG and FFA levels. Both groups of infants significantly increased the concentration of ketone bodies; however, there was no difference in the levels achieved. In view of the slower clearance rate of TG and the higher levels of FFA in SGA infants, it is speculated that in addition to a possible defective lipoprotein lipase system and a decrease in number and size of the adipose cells, beta-oxidation of FFA to ketones may be occurring at a slower rate. The generation of high levels of ketones during Intralipid infusion period in both groups of infants indicates that SGA infants can handle ketone bodies as readily as AGA infants.
在两组婴儿中研究了英脱利匹特（Intralipid）的生酮潜力：12名小于胎龄儿（SGA）和15名适于胎龄儿（AGA）；所有婴儿临床状况稳定且年龄小于48小时。在4小时的英脱利匹特耐受性测试期间，小于胎龄儿的血浆甘油三酯（TG）和游离脂肪酸（FFA）水平显著更高。两组婴儿的酮体浓度均显著升高；然而，所达到的水平没有差异。鉴于小于胎龄儿中甘油三酯清除率较慢且游离脂肪酸水平较高，推测除了可能存在的脂蛋白脂肪酶系统缺陷以及脂肪细胞数量和大小减少外，游离脂肪酸向酮体的β氧化可能以较慢的速率发生。两组婴儿在英脱利匹特输注期间均产生高水平的酮体，这表明小于胎龄儿与适于胎龄儿一样能够轻易地处理酮体。
