3'-脱氧腺苷（虫草素）的抗真菌活性。
Antifungal activity of 3'-deoxyadenosine (cordycepin).
作者信息
Sugar A M, McCaffrey R P
机构信息
Evans Memorial Department of Clinical Research, Boston Medical Center, Massachusetts, USA.
出版信息
Antimicrob Agents Chemother. 1998 Jun;42(6):1424-7. doi: 10.1128/AAC.42.6.1424.
Abstract
The antifungal activity of the nucleoside analog 3'-deoxyadenosine (cordycepin) was studied in a murine model of invasive candidiasis. When protected from deamination by either deoxycoformycin or coformycin, both of which are adenosine deaminase inhibitors, cordycepin exhibited potent antifungal efficacy, as demonstrated by prolongation of survival and a decrease in CFU in the kidneys of mice treated with cordycepin plus an adenosine deaminase inhibitor. The antifungal effect was seen with three different Candida isolates: Candida albicans 64, a relatively fluconazole-resistant clinical isolate of C. albicans (MIC, 16 micrograms/ml), and the fluconazole-resistant Candida krusei. Cordycepin and related compounds may provide another avenue for the discovery of clinically useful antifungal drugs.
摘要
在侵袭性念珠菌病的小鼠模型中研究了核苷类似物3'-脱氧腺苷（虫草素）的抗真菌活性。当通过脱氧助间型霉素或助间型霉素（二者均为腺苷脱氨酶抑制剂）防止脱氨时，虫草素表现出强大的抗真菌功效，这在接受虫草素加腺苷脱氨酶抑制剂治疗的小鼠肾脏中，通过生存期延长和菌落形成单位减少得以证明。对三种不同的念珠菌分离株均观察到了抗真菌作用：白色念珠菌64，一种对氟康唑相对耐药的白色念珠菌临床分离株（最低抑菌浓度，16微克/毫升），以及耐氟康唑的克鲁斯念珠菌。虫草素及相关化合物可能为发现临床上有用的抗真菌药物提供另一条途径。
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