两性霉素B与SCH 39304联合治疗实验性小鼠念珠菌病的相互作用：多烯-唑类联合用药无拮抗作用。
Interactions of amphotericin B and SCH 39304 in the treatment of experimental murine candidiasis: lack of antagonism of a polyene-azole combination.
作者信息
Sugar A M
机构信息
Evans Memorial Department of Clinical Research, Boston University Medical Center, Massachusetts 02118.
出版信息
Antimicrob Agents Chemother. 1991 Aug;35(8):1669-71. doi: 10.1128/AAC.35.8.1669.
Abstract
Mice infected intravenously with Candida albicans were treated with SCH 39304, a new triazole antifungal compound, amphotericin B, or both. Two dose levels of each drug were evaluated in an attempt to identify potential helpful or harmful effects on survival and kidney colony counts. Contrary to theoretical predictions, combination therapy was not antagonistic and some additive or synergistic effects were observed. The results obtained in this study suggest that antagonism between polyene and azole antifungal drugs is not inevitable and that additive or synergistic effects may be possible.
摘要
用新型三唑类抗真菌化合物SCH 39304、两性霉素B或两者对经静脉注射感染白色念珠菌的小鼠进行治疗。对每种药物的两个剂量水平进行了评估，以试图确定对生存和肾脏菌落计数的潜在有益或有害影响。与理论预测相反，联合治疗并非拮抗作用，而是观察到了一些相加或协同作用。本研究获得的结果表明，多烯类和唑类抗真菌药物之间的拮抗作用并非不可避免，相加或协同作用可能是存在的。
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本文引用的文献
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