锌指活性药物对蓝氏贾第鞭毛虫的疗效。
Efficacies of zinc-finger-active drugs against Giardia lamblia.
作者信息
Nash T, Rice W G
机构信息
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Antimicrob Agents Chemother. 1998 Jun;42(6):1488-92. doi: 10.1128/AAC.42.6.1488.
Abstract
Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 microM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 +/- 0.32 microM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.
摘要
在300微摩尔及以下浓度时，34种锌指活性化合物中有29种（85%）抑制了蓝氏贾第鞭毛虫的生长。活性最强的化合物双硫仑（戒酒硫）在1.23±0.32微摩尔时具有杀原虫作用。在成年小鼠模型中，治愈率提高和寄生虫负荷降低证明了显著的体内活性。
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