Olinici C D, Giurgiuman M, Galatâr N, Lazarov P, Mârza V
Arch Geschwulstforsch. 1976;46(2):129-39.
Fifty nine effusions (6 from patients with benign diseases and 53 from cancer patients) were examined cytologically and cytogenetically. Only diploid cells were observed in the benign effusions. The majority of malignant effusions had chromosomal changes, but in three cases where cytologic examination had revealed the presence of malignant cells, only diploid metaphases were found. No false positive diagnoses were made either by the cytologic or by the cytogenetic technique. The concomitant use of cytologic and cytogenetic examinations has substantially improved the correctness of the diagnosis. If by cytologic examination 43 of the 53 effusions from cancer patients were diagnosed as positive, 4 as suspicious and 6 as negative, the combined results of the cytologic and cytogenetic examination can be summarized in 49 positive, 1 suspicious and 3 negative cases. The implications of these data for the medical practice are briefly discussed.
对59例积液（6例来自良性疾病患者，53例来自癌症患者）进行了细胞学和细胞遗传学检查。在良性积液中仅观察到二倍体细胞。大多数恶性积液有染色体变化，但在3例细胞学检查已显示存在恶性细胞的病例中，仅发现二倍体中期。细胞学或细胞遗传学技术均未出现假阳性诊断。细胞学和细胞遗传学检查的联合应用显著提高了诊断的正确性。如果通过细胞学检查，53例癌症患者的积液中有43例被诊断为阳性，4例为可疑，6例为阴性，那么细胞学和细胞遗传学检查的联合结果可总结为49例阳性，1例可疑和3例阴性。简要讨论了这些数据对医疗实践的意义。
