Hill J O, Seagle H M, Johnson S L, Smith S, Reed G W, Tran Z V, Cooper D, Stone M, Peters J C
Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA.
Am J Clin Nutr. 1998 Jun;67(6):1178-85. doi: 10.1093/ajcn/67.6.1178.
We conducted a double-blind, placebo-controlled, within-subject crossover study to investigate the effects of covert substitution of olestra, a non-energy-containing fat replacer, for conventional fat on food selection and energy intake in lean and obese men and women. Fifty-one subjects [BMI (kg/m2): 19-36; age: 25-63 y] were studied during two 14-d treatment periods (olestra and placebo), with a 7-d washout between feeding periods. During the intervention periods all foods were provided to the subjects. The aim was to produce a 10% dilution of total energy intake by replacing conventional triacylglycerol with olestra. To accomplish this, subjects were required to consume core foods providing 20-35 g olestra (depending on estimated energy needs) or the same foods containing placebo triacylglycerol. Additional items could be selected from foods that varied in macronutrient composition. When the two treatment periods were compared, total energy intake was 8% lower and fat intake 11% lower during the olestra period than during the placebo treatment period (P < 0.0001). Overall, subjects compensated for 15% of the fat and 20% of the total energy replaced by olestra. In absolute terms, subjects consumed 32% of total energy from fat during the placebo period and 27% of total energy from fat during the olestra period. Neither carbohydrate nor protein intake (g/d) differed between periods. The results did not differ as a function of BMI (lean compared with obese) or sex. Over a 2-wk period, covert substitution of olestra for conventional fat led to reductions in dietary fat intake and total energy intake in all subjects.
我们进行了一项双盲、安慰剂对照、受试者内交叉研究，以调查用非能量型脂肪替代品蔗糖聚酯暗中替代传统脂肪对瘦型和肥胖型男性及女性食物选择和能量摄入的影响。51名受试者[体重指数（kg/m²）：19 - 36；年龄：25 - 63岁]在两个为期14天的治疗期（蔗糖聚酯和安慰剂）内接受研究，喂食期之间有7天的洗脱期。在干预期内，所有食物都提供给受试者。目的是通过用蔗糖聚酯替代传统三酰甘油使总能量摄入稀释10%。为实现这一目标，要求受试者食用提供20 - 35克蔗糖聚酯（取决于估计的能量需求）的核心食物或含有安慰剂三酰甘油的相同食物。其他食物可从宏量营养素组成不同的食物中选择。比较两个治疗期时，蔗糖聚酯期的总能量摄入比安慰剂治疗期低8%，脂肪摄入低11%（P < 0.0001）。总体而言，受试者补偿了蔗糖聚酯替代的15%的脂肪和20%的总能量。从绝对值来看，受试者在安慰剂期从脂肪中摄入的能量占总能量的32%，在蔗糖聚酯期从脂肪中摄入的能量占总能量的27%。两个时期的碳水化合物和蛋白质摄入量（克/天）均无差异。结果不受体重指数（瘦型与肥胖型）或性别的影响。在为期2周的时间里，用蔗糖聚酯暗中替代传统脂肪导致所有受试者的膳食脂肪摄入量和总能量摄入量减少。
