食管癌的变化趋势：单中心15年经验

Changing trends in esophageal cancer: a 15-year experience in a single center.

作者信息

Sharma V K, Chockalingam H, Hornung C A, Vasudeva R, Howden C W

机构信息

Department of Internal Medicine, University of South Carolina, Columbia 29203-6808, USA.

出版信息

Am J Gastroenterol. 1998 May;93(5):702-5. doi: 10.1111/j.1572-0241.1998.209_a.x.

DOI:10.1111/j.1572-0241.1998.209_a.x

PMID:9625112

Abstract

OBJECTIVE

Esophageal adenocarcinoma is increasing in white men. We sought to identify trends in esophageal cancer in different patient groups in our region.

METHODS

We reviewed the records of all patients with esophageal cancer seen at two hospitals in Columbia, SC between 1981 and 1995. Patients were divided into three cohorts (1981-1985, 1986-1990, and 1991-1995). Demographic data, histological type, tumor stage, grade, and survival were recorded.

RESULTS

Histology was available in 371 of 386 patients (cohort 1, 113 patients; cohort 2, 144; and cohort 3, 114). Adenocarcinoma accounted for 24%, 27%, and 49% of esophageal cancer in white men in cohorts 1, 2, and 3, respectively (p = 0.03). Corresponding figures for African-Americans were 10%, 7%, and 3% (p = 0.22). Women comprised 8%, 14%, and 22% of patients with squamous carcinoma in the three cohorts (p = 0.03). Median survival for esophageal cancer was 6.0, 6.8, and 10.4 mo in cohorts 1, 2, and 3 (p = 0.0002).

CONCLUSION

Adenocarcinoma is increasing in whites. Squamous carcinoma remains the predominant type in this region, seen mainly in African-Americans. Esophageal squamous carcinoma is increasing in women. The mean age at diagnosis of squamous carcinoma has decreased in whites. There is a trend toward improved survival in patients with esophageal cancer.

摘要

目的

食管腺癌在白人男性中的发病率呈上升趋势。我们试图确定本地区不同患者群体中食管癌的发病趋势。

方法

我们回顾了1981年至1995年间在南卡罗来纳州哥伦比亚市两家医院就诊的所有食管癌患者的记录。患者被分为三个队列（1981 - 1985年、1986 - 1990年和1991 - 1995年）。记录了人口统计学数据、组织学类型、肿瘤分期、分级和生存率。

结果

386例患者中有371例有组织学资料（队列1，113例患者；队列2，144例；队列3，114例）。腺癌在队列1、2和3的白人男性食管癌中分别占24%、27%和49%（p = 0.03）。非裔美国人的相应数字分别为10%、7%和3%（p = 0.22）。在三个队列中，女性分别占鳞状细胞癌患者的8%、14%和22%（p = 0.03）。队列1、2和3中食管癌的中位生存期分别为6.0、6.8和10.4个月（p = 0.0002）。