质子泵抑制剂每日两次给药时胃酸分泌的夜间恢复情况。
Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton pump inhibitors.
作者信息
Peghini P L, Katz P O, Bracy N A, Castell D O
机构信息
The Esophageal Research Laboratory, Allegheny University Hospitals, Graduate, Philadelphia, Pennsylvania 19146, USA.
出版信息
Am J Gastroenterol. 1998 May;93(5):763-7. doi: 10.1111/j.1572-0241.1998.221_a.x.
OBJECTIVES
It is our experience that many patients treated with proton pump inhibitors (PPI) b.i.d. recover acid secretion during the night. Our aim was to assess the efficacy of omeprazole and lansoprazole b.i.d. on nocturnal gastric acidity.
METHODS
Three groups were studied with intragastric pH monitoring. Group 1 consisted of 17 patients with gastroesophageal reflux disease (GERD) taking omeprazole 20 mg b.i.d. Group 2 was 16 male volunteers taking omeprazole 20 mg b.i.d. and Group 3 comprised 12 volunteers taking lansoprazole 30 mg b.i.d.
RESULTS
The percentages of time that subjects had pH < 4 were lower during supine than upright periods in Groups 1 and 3 (P < 0.01). Recovery of nocturnal acid secretion lasting > 1 h, termed acid breakthrough, occurred in three-fourths of all individuals within 12 h from intake of the evening dose of PPI. Median time to acid breakthrough for the whole group was 7.5 h.
CONCLUSION
Nocturnal acid breakthrough occurs in a majority of patients and normal volunteers taking PPI b.i.d.
目的
根据我们的经验，许多接受质子泵抑制剂（PPI）每日两次治疗的患者夜间会恢复胃酸分泌。我们的目的是评估奥美拉唑和兰索拉唑每日两次对夜间胃酸度的疗效。
方法
通过胃内pH监测对三组进行研究。第一组由17例服用20mg奥美拉唑每日两次的胃食管反流病（GERD）患者组成。第二组是16名服用20mg奥美拉唑每日两次的男性志愿者，第三组由12名服用30mg兰索拉唑每日两次的志愿者组成。
结果
在第一组和第三组中，受试者仰卧位时pH<4的时间百分比低于直立位（P<0.01）。夜间胃酸分泌恢复持续>1小时，即所谓的酸突破，在摄入晚间剂量PPI后的12小时内，四分之三的个体出现这种情况。整个组酸突破的中位时间为7.5小时。
结论
大多数服用PPI每日两次的患者和正常志愿者会出现夜间酸突破。
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