狒狒感染人类免疫缺陷病毒2型是人类免疫缺陷病毒在人体内发病机制的动物模型。

Human immunodeficiency virus-2 infection in baboons is an animal model for human immunodeficiency virus pathogenesis in humans.

作者信息

Locher C P, Barnett S W, Herndier B G, Blackbourn D J, Reyes-Terán G, Murthy K K, Brasky K M, Hubbard G B, Reinhart T A, Haase A T, Levy J A

机构信息

Department of Medicine, University of California, San Francisco, 94143-1270, USA.

出版信息

Arch Pathol Lab Med. 1998 Jun;122(6):523-33.

PMID:9625420

Abstract

OBJECTIVE

To assess disease progression in baboons (Papio cynocephalus) that were infected with two human immunodeficiency virus-2 (HIV-2) isolates.

METHODS

Eight baboons were inoculated intravenously with either HIV-2UC2 or HIV-2UC14 and were followed for a 2- to 7-year period of observation.

RESULTS

Six of 8 baboons showed lymphadenopathy and other signs of HIV-related disease, 3 of 8 baboons had an acute phase CD4+ T-cell decline, and 2 of 5 baboons infected with the HIV-2UC2 isolate progressed to an acquired immunodeficiency syndrome-like disease. Human immunodeficiency virus-2-specific pathology in lymphatic tissues included follicular lysis, vascular proliferation, and lymphoid depletion. Both neutralizing antibodies and a CD8+ T-cell antiviral response were associated with resistance to disease.

CONCLUSIONS

Disease progression and the development of acquired immunodeficiency syndrome in HIV-2-infected baboons have similarities to human HIV infections.

摘要

目的

评估感染两种人类免疫缺陷病毒2型（HIV-2）分离株的狒狒（黄狒）的疾病进展情况。

方法

8只狒狒通过静脉接种HIV-2UC2或HIV-2UC14，并进行了2至7年的观察。

结果

8只狒狒中有6只出现淋巴结病及其他与HIV相关疾病的体征，8只狒狒中有3只急性期CD4+T细胞数量下降，感染HIV-2UC2分离株的5只狒狒中有2只进展为获得性免疫缺陷综合征样疾病。淋巴组织中HIV-2特异性病理表现包括滤泡溶解、血管增生和淋巴细胞耗竭。中和抗体和CD8+T细胞抗病毒反应均与疾病抗性相关。