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人类免疫缺陷病毒2型衣壳的单个氨基酸在食蟹猴和人类TRIM5α存在的情况下会影响其复制。

A single amino acid of the human immunodeficiency virus type 2 capsid affects its replication in the presence of cynomolgus monkey and human TRIM5alphas.

作者信息

Song Haihan, Nakayama Emi E, Yokoyama Masaru, Sato Hironori, Levy Jay A, Shioda Tatsuo

机构信息

Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-Oka, Suita, Osaka 565-0871, Japan.

出版信息

J Virol. 2007 Jul;81(13):7280-5. doi: 10.1128/JVI.00406-07. Epub 2007 May 2.

DOI:10.1128/JVI.00406-07
PMID:17475650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1933286/
Abstract

Human immunodeficiency virus type 2 (HIV-2) strains vary widely in their abilities to grow in Old World monkey (OWM) cells such as those of cynomolgus monkeys (CM). We evaluated eight HIV-2 isolates for their sensitivities to CM TRIM5alpha, an anti-HIV factor in OWM cells. We found that different HIV-2 isolates showed differences in their sensitivities to CM TRIM5alpha. Sequence analysis showed that TRIM5alpha-sensitive viruses had proline at the 120th position of the capsid protein (CA), whereas TRIM5alpha-resistant viruses had either alanine or glutamine. Mutagenesis studies indicated that the single amino acid at the 120th position indeed affected the sensitivity of the virus to CM TRIM5alpha.

摘要

2型人类免疫缺陷病毒（HIV-2）毒株在旧世界猴（OWM）细胞（如食蟹猴（CM）细胞）中的生长能力差异很大。我们评估了8株HIV-2分离株对CM TRIM5α（一种OWM细胞中的抗HIV因子）的敏感性。我们发现不同的HIV-2分离株对CM TRIM5α的敏感性存在差异。序列分析表明，对TRIM5α敏感的病毒在衣壳蛋白（CA）的第120位有脯氨酸，而对TRIM5α耐药的病毒在该位置则为丙氨酸或谷氨酰胺。诱变研究表明，第120位的单个氨基酸确实影响了病毒对CM TRIM5α的敏感性。

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本文引用的文献

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Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity.负责逆转录病毒限制活性和特异性的人类三重基序5α结构域。
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A specific region of 37 amino acid residues in the SPRY (B30.2) domain of African green monkey TRIM5alpha determines species-specific restriction of simian immunodeficiency virus SIVmac infection.非洲绿猴TRIM5α的SPRY（B30.2）结构域中一段由37个氨基酸残基组成的特定区域决定了猿猴免疫缺陷病毒SIVmac感染的物种特异性限制。
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HIV-1 proteases from drug-naive West African patients are differentially less susceptible to protease inhibitors.来自未接受过药物治疗的西非患者的HIV-1蛋白酶对蛋白酶抑制剂的敏感性存在差异，较低。
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