Julian-Reynier C, Eisinger F, Chabal F, Aurran Y, Bignon Y J, Nogues C, Machelard M, Maugard C, Vennin P, Sobol H
INSERM U379, Centre Regional de Lutte contre le Cancer, 13273 Marseille, Cedex 9, France.
Oncol Rep. 1998 Jul-Aug;5(4):885-8. doi: 10.3892/or.5.4.885.
The aim of this study was to investigate the effects of cancer genetic consultations on feelings of anxiety in women with breast/ovarian cancer. Among the 138 women attending six French clinics during a one-year period, 115 (83.3%) answered pre- and post-consultation questionnaires. The state anxiety score (Spielberger's STAI) was lower (paired t-test, p<0.001) after the consultation (34.7 9.4) than before (38.8 10.5). The time elapsing since cancer diagnosis (r=-0.28, p=0.007) was the main predictor of the decrease in anxiety. The patients consulting earlier after their cancer was diagnosed were more anxious before the consultation than those consulting later: whereas their anxiety states after the consultation were similar. The consultation effectively decreased the anxiety observed and the anxiety felt by cancer patients before the consultation may constitute an anticipatory stress response that should be investigated.
本研究的目的是调查癌症遗传咨询对乳腺癌/卵巢癌女性焦虑情绪的影响。在为期一年的时间里，138名在法国六家诊所就诊的女性中，有115名（83.3%）回答了咨询前后的问卷。咨询后状态焦虑评分（斯皮尔伯格状态-特质焦虑问卷的状态焦虑量表）（34.7±9.4）低于咨询前（38.8±10.5）（配对t检验，p<0.001）。自癌症诊断以来的时间（r=-0.28，p=0.007）是焦虑减轻的主要预测因素。癌症诊断后较早咨询的患者在咨询前比晚些咨询的患者更焦虑：而他们咨询后的焦虑状态相似。咨询有效地减轻了观察到的焦虑，癌症患者在咨询前感受到的焦虑可能构成一种预期性应激反应，值得研究。
