Julian-Reynier C, Eisinger F, Chabal F, Aurran Y, Bignon Y J, Noguès C, Machelard M, Maugard C, Vennin P, Sobol H
INSERUM U379, Centre Régional de Lutte contre le Cancer, Marseille, France.
Eur J Cancer. 1998 Sep;34(10):1549-53. doi: 10.1016/s0959-8049(98)00164-6.
Cancer patients attend oncogenetic clinics so that the existence of a genetic risk can be checked and the relatives informed. The aim of this study was to describe the expectations of cancer patients about genetic counselling and their beliefs about the aetiology of their disease. A survey based on self-administered questionnaires before and after the consultation was carried out on 115 women with breast/ovarian cancer who attended one of the six French participating clinics. In 59 cases (51%), the consultees' expectations focused on the preventive options available and in 86 cases (75%) on their offspring; 87 (76%) found the consultation informative. On average, the women rated heredity and diet as lower risk factors (P < 0.05) after the consultation than before. Heredity, stress and the environment were thought to be more decisive than diet, smoking and alcohol. 34 patients who seemed unlikely to have a genetic risk in the consultant's opinion thought heredity to be less relevant (P < 0.05) after the consultation than before. At the time of the survey, cancer patients accounted for at least half of the consultees attending oncogenetic clinics in France. They need to have the clinical specificities of their disease and its medical management explained. They attend mainly for their offspring's sake, whereas healthy clients attend for their own sake.
癌症患者前往肿瘤遗传学诊所，以便检查是否存在遗传风险并通知其亲属。本研究的目的是描述癌症患者对遗传咨询的期望以及他们对自身疾病病因的看法。对在法国六个参与研究的诊所之一就诊的115名乳腺癌/卵巢癌女性患者进行了一项基于咨询前后自行填写问卷的调查。59例（51%）咨询者的期望集中在可用的预防措施上，86例（75%）集中在其后代身上；87例（76%）认为咨询内容丰富。平均而言，这些女性在咨询后认为遗传和饮食是风险较低的因素（P < 0.05），低于咨询前。她们认为遗传、压力和环境比饮食、吸烟和饮酒更具决定性。在咨询医生看来不太可能存在遗传风险的34名患者在咨询后认为遗传因素的相关性低于咨询前（P < 0.05）。在调查时，癌症患者至少占法国肿瘤遗传学诊所咨询者的一半。他们需要了解自身疾病的临床特点及其医疗处理方式。他们主要是为了子女而来就诊，而健康的咨询者则是为了自己。
