Antoine J C, Mosnier J F, Honnorat J, Convers P, Absi L, Lapras J, Michel D
Department of Neurology, Hôpital de Bellevue, Saint-Etienne, France.
Muscle Nerve. 1998 Jul;21(7):850-7. doi: 10.1002/(sici)1097-4598(199807)21:7<850::aid-mus2>3.0.co;2-5.
A patient with anti-Hu antibodies, small-cell lung carcinoma, and autopsy-proven subacute sensory neuropathy had early slowing of motor and sensory conduction velocities. In the peripheral nerves, chronic demyelinating and remyelinating lesions with axonal degeneration were associated with an inflammatory reaction consisting of CD8+ T cells and CD68+ macrophages. On immunohistochemical testing, the patient's serum did not react with normal nerve, suggesting that the Hu proteins were not the target of the inflammatory reaction in the nerve.
一名患有抗Hu抗体、小细胞肺癌且经尸检证实患有亚急性感觉神经病变的患者，其运动和感觉传导速度早期减慢。在周围神经中，伴有轴突变性的慢性脱髓鞘和再髓鞘化病变与由CD8 + T细胞和CD68 +巨噬细胞组成的炎症反应相关。免疫组织化学检测显示，患者血清与正常神经无反应，这表明Hu蛋白不是神经炎症反应的靶点。
