Tontis A, Meier W
Institut für Tierpathologie, Universität Bern.
Tierarztl Prax Ausg G Grosstiere Nutztiere. 1998 Feb;26(1):24-8.
The white liver disease was first observed in the canton of Berne in 1985. Until 1995 we could observe the outbreak of the disease in seven flocks. The first clinical signs were anorexia, then delayed growth, weight loss and finally cachexy. The animals showed photosensitivity on ears, eyelids and nose. A hematological and blood biochemical examination revealed a mild normochrome, normocytic anemia as well as a significant elevation of GGT and a mild elevation of AST values. By examining the swollen grey-white to yellow livers histologically we could find a mostly pronounced, primarily panacinar, degenerative fatty degeneration of the liver, ceroid pigment in the macrophages, biliary hyperplasia as well as a secondary periportal hepatitis.
1985年，白肝病首次在伯尔尼州被发现。到1995年，我们观察到该病在7个鸡群中爆发。最初的临床症状是厌食，随后是生长迟缓、体重减轻，最终出现恶病质。患病动物的耳朵、眼睑和鼻子出现光敏反应。血液学和血液生化检查显示轻度正色素、正细胞性贫血，以及γ-谷氨酰转移酶（GGT）显著升高和天冬氨酸转氨酶（AST）值轻度升高。通过对肿胀的灰白色至黄色肝脏进行组织学检查，我们发现肝脏大多出现明显的、主要为全小叶性的退行性脂肪变性，巨噬细胞中有类脂色素，胆管增生以及继发性汇管区周围肝炎。
