Raynaud J S, Bridal S L, Toussaint J F, Fornès P, Lebon V, Berger G, Leroy-Willig A
Service Hospitalier Fridiric Joliot, DRM-CEA, Orsay, France.
J Magn Reson Imaging. 1998 May-Jun;8(3):622-9. doi: 10.1002/jmri.1880080316.
High resolution MRI at 3 T and US imaging at 50 MHz were used for atherosclerotic plaque characterization. For 14 excised segments of human arteries, conventional MR and US images, quantitative MR T2 maps, US integrated attenuation (IA) maps, and histologic sections were produced and compared. The MR T2 and US attenuation mean values estimated in selected regions of interest were related with tissue type as identified on histologic sections. Significant distinction between media or collagen and lipid or collagen lipidic plaque was achieved with both techniques (MR: P < .001; US: P < .01). Significant distinction was obtained between media and collagen (P < .0001) and between iliac and aortic media (P < .05) with MR T2 but not with IA. MR and US native and parametric images, with different sensitivities to tissue type, provide complementary information useful for quantitative plaque characterization.
使用3T高分辨率MRI和50MHz超声成像对动脉粥样硬化斑块进行特征分析。对14个切除的人体动脉节段，制作并比较了传统MR和超声图像、定量MR T2图、超声积分衰减（IA）图以及组织学切片。在选定的感兴趣区域估计的MR T2和超声衰减平均值与组织学切片上确定的组织类型相关。两种技术（MR：P <.001；超声：P <.01）均能在中膜或胶原与脂质或胶原脂质斑块之间实现显著区分。通过MR T2可在中膜和胶原之间（P <.0001）以及髂动脉和主动脉中膜之间（P <.05）实现显著区分，但IA不能。MR和超声的原始图像及参数图像对组织类型具有不同的敏感性，可提供有助于定量斑块特征分析的互补信息。
