Loewe C, Oberhuber G, Loewe R, Frank H
Abt. für Kardiologie, Universität Wien.
Z Kardiol. 1998 Aug;87(8):622-9. doi: 10.1007/s003920050221.
Magnetic resonance (MR) imaging studies have allowed the imaging of an atheroma, its size, shape, and lipid contents. The aim of our study was to characterize atherosclerotic lesions using a 0.5 T magnet, to delineate plaque components, and to compare MR results with histology. Thirty necropsy specimens of human iliac arteries were studied. Magnetic resonance imaging studies were carried out on a 0.5 Tesla superconducting magnet using a 5 cm surface coil. The position for the coronal MR planes was oriented by an external marker. The matrix size was 256 x 256, 4 NEX, and the FOV was 45 mm. The pulse sequences used included SE 520/29 and SE 2200/28 and 90. Signal intensity (SI) of fibrous plaques increased significantly from 28.3 +/- 3.8 to 49.1 +/- 8.2 (p < or = 0.0001) and decreased at SE 2200/90 to 24.1 +/- 6.8 (p < or = 0.0001). However, lipid plaque components showed no significant change in SI between T1-weighted pulse-sequences (28.2 +/- 5.4) and T2-weighted pulse-sequences (25.5 +/- 5.9). Only at SE 2200/90 SI of lipid plaques decreased significantly (11.8 +/- 3.9, p < or = 0.0001). As compared to histology, MR has shown a high sensitivity and specificity in the detection of fibrous and lipid plaque components. In conclusions, our study demonstrated that MR is highly effective in the characterization of atherosclerotic lesions.
磁共振（MR）成像研究已能够对动脉粥样硬化斑块进行成像，包括其大小、形状和脂质含量。我们研究的目的是使用0.5T磁体对动脉粥样硬化病变进行特征描述，描绘斑块成分，并将MR结果与组织学结果进行比较。我们研究了30个尸检获得的人髂动脉标本。使用5cm表面线圈在0.5特斯拉超导磁体上进行磁共振成像研究。冠状面MR平面的位置通过外部标记物进行定位。矩阵大小为256×256，4次激励，视野为45mm。使用的脉冲序列包括SE 520/29、SE 2200/28和90。纤维斑块的信号强度（SI）从28.3±3.8显著增加至49.1±8.2（p≤0.0001），在SE 2200/90时降至24.1±6.8（p≤0.0001）。然而，脂质斑块成分在T1加权脉冲序列（28.2±5.4）和T2加权脉冲序列（25.5±5.9）之间的SI没有显著变化。仅在SE 2200/90时，脂质斑块的SI显著降低（11.8±3.9，p≤0.0001）。与组织学相比，MR在检测纤维和脂质斑块成分方面显示出高敏感性和特异性。总之，我们的研究表明MR在动脉粥样硬化病变的特征描述方面非常有效。
