人胃肠道黏蛋白和乳糖蛋白对幽门螺杆菌唾液酸特异性血凝反应的抑制作用
Inhibition of Helicobacter pylori sialic acid-specific haemagglutination by human gastrointestinal mucins and milk glycoproteins.
作者信息
Hirmo S, Kelm S, Iwersen M, Hotta K, Goso Y, Ishihara K, Suguri T, Morita M, Wadström T, Schauer R
机构信息
Institute of Medical Microbiology, University of Lund, Sweden.
出版信息
FEMS Immunol Med Microbiol. 1998 Apr;20(4):275-81. doi: 10.1111/j.1574-695X.1998.tb01137.x.
Abstract
Helicobacter pylori, a human gastric pathogen causing chronic gastritis and duodenal ulcer disease, has been found in large amounts in gastric mucous gel layer. Mucin preparations, separated from human gastric juices and isolated from different colon regions, were examined for their ability to inhibit haemagglutination of H. pylori with the emphasis on evaluating the role of sialic acid-dependent haemagglutinins of the bacteria in colonisation of the stomach. The mucins showed high inhibitory activity for H. pylori, which was significantly decreased after the removal of sialic acids from the mucins. The inhibitory potencies using high molecular mass mucin-like components from bovine milk were comparable with those obtained for gastric mucins, suggesting their possible role in the prevention of H. pylori infection.
摘要
幽门螺杆菌是一种导致慢性胃炎和十二指肠溃疡病的人类胃部病原体，已在胃黏液凝胶层中大量发现。对从人胃液中分离并从不同结肠区域分离出的黏液制剂进行了检测，以评估其抑制幽门螺杆菌血凝的能力，重点是评估该细菌的唾液酸依赖性血凝素在胃部定植中的作用。黏液对幽门螺杆菌表现出高抑制活性，在从黏液中去除唾液酸后，这种活性显著降低。使用来自牛乳的高分子量类黏蛋白成分的抑制效力与胃黏液的抑制效力相当，表明它们在预防幽门螺杆菌感染中可能发挥的作用。
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