Mentis A, Tzouvelekis L, Spiliadis C, Blackwell C C, Weir D M
Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
FEMS Microbiol Immunol. 1990 Oct;2(3):125-7. doi: 10.1111/j.1574-6968.1990.tb03511.x.
Thirty isolates of Helicobacter pylori from gastric biopsies agglutinated human erythrocyte suspensions. Crude mucin preparations derived from saliva of 20 different donors were examined for their ability to inhibit haemagglutination. All mucin preparations exhibited strong inhibitory activity. Removal of sialic residues from mucin preparations by treatment with neuraminidase resulted in a substantial reduction of their inhibitory activity. The mucin preparations had no bactericidal or aggregation activity for H. pylori. These results are discussed in the context of the role of mucins in colonization of the gastric mucosa by H. pylori.
从胃活检中分离出的30株幽门螺杆菌凝集了人红细胞悬液。检测了来自20位不同捐赠者唾液的粗粘蛋白制剂抑制血凝的能力。所有粘蛋白制剂均表现出强烈的抑制活性。用神经氨酸酶处理粘蛋白制剂以去除唾液酸残基，导致其抑制活性大幅降低。粘蛋白制剂对幽门螺杆菌没有杀菌或聚集活性。本文结合粘蛋白在幽门螺杆菌定植胃黏膜中的作用对这些结果进行了讨论。
