Jin Y, Bunney W E, Sandman C A, Patterson J V, Fleming K, Moenter J R, Kalali A H, Hetrick W P, Potkin S G
Department of Psychiatry and Human Behavior, University of California Irvine Medical Center, Orange 92868-3298, USA.
Biol Psychiatry. 1998 Jun 15;43(12):873-8. doi: 10.1016/s0006-3223(98)00115-2.
Abnormal P50 response has been hypothesized to reflect the sensory gating deficit in schizophrenia. Despite the extensive literature concerning the sensory filtering or gating deficit in schizophrenia, no evidence has been provided to test the relationship of the P50 phenomenon with patients' experiences of perceptual anomalies.
Sixteen drug-free DSM-IV diagnosed schizophrenic patients who reported moderate to severe perceptual anomalies in the auditory or visual modality were examined as compared to 16 schizophrenic patients who did not report perceptual anomalies, and 16 normal subjects. Both control groups were age- and gender-matched with the study group.
Patients reporting perceptual anomalies exhibited P50 patterns that did not differ from normal subjects. In contrast, patients who did not report perceptual anomalies showed the abnormal P50 ratios previously found to be associated with schizophrenia.
These paradoxical findings do not support the hypothetical relationship between the P50 and behavioral measures of sensory gating, suggesting that additional studies are needed to further explore the clinical correlates of the P50.
异常的P50反应被认为反映了精神分裂症患者的感觉门控缺陷。尽管有大量关于精神分裂症患者感觉过滤或门控缺陷的文献，但尚无证据检验P50现象与患者感知异常体验之间的关系。
选取16名符合DSM-IV诊断标准且未服用药物的精神分裂症患者，这些患者报告在听觉或视觉方面存在中度至重度感知异常，将其与16名未报告感知异常的精神分裂症患者及16名正常受试者进行比较。两个对照组在年龄和性别上与研究组相匹配。
报告有感知异常的患者表现出与正常受试者无异的P50模式。相比之下，未报告感知异常的患者呈现出先前发现与精神分裂症相关的异常P50比率。
这些矛盾的发现不支持P50与感觉门控行为指标之间的假设关系，表明需要进一步研究以深入探讨P50的临床相关因素。
