Romero I, Fuertes A, Benito M J, Malpica J M, Leyva A, Paz-Ares J
Centro Nacional de Biotecnología-CSIC, Madrid, Spain.
Plant J. 1998 May;14(3):273-84. doi: 10.1046/j.1365-313x.1998.00113.x.
Transcription factors belonging to the R2R3-MYB family contain the related helix-turn-helix repeats R2 and R3. The authors isolated partial cDNA and/or genomic clones of 78 R2R3-MYB genes from Arabidopsis thaliana and found accessions corresponding to 31 Arabidopsis genes of this class in databanks, seven of which were not represented in the authors' collection. Therefore, there are at least 85, and probably more than 100, R2R3-MYB genes present in the Arabidopsis thaliana genome, representing the largest regulatory gene family currently known in plants. In contrast, no more than three R2R3-MYB genes have been reported in any organism from other phyla. DNA-binding studies showed that there are differences but also frequent overlaps in binding specificity among plant R2R3-MYB proteins, in line with the distinct but often related functions that are beginning to be recognized for these proteins. This large-sized gene family may contribute to the regulatory flexibility underlying the developmental and metabolic plasticity displayed by plants.
属于R2R3-MYB家族的转录因子包含相关的螺旋-转角-螺旋重复序列R2和R3。作者从拟南芥中分离出78个R2R3-MYB基因的部分cDNA和/或基因组克隆，并在数据库中发现了与该类31个拟南芥基因相对应的登录号，其中7个在作者的收集中未出现。因此，拟南芥基因组中至少存在85个，可能超过100个R2R3-MYB基因，代表了目前已知的植物中最大的调控基因家族。相比之下，在其他门的任何生物中报道的R2R3-MYB基因不超过3个。DNA结合研究表明，植物R2R3-MYB蛋白之间在结合特异性上存在差异，但也经常重叠，这与这些蛋白开始被认识到的独特但通常相关的功能一致。这个大型基因家族可能有助于植物所表现出的发育和代谢可塑性背后的调控灵活性。
