Mukai M, Uchimura N, Hirano T, Ohshima H, Ohshima M, Nakamura J
Department of Neuropsychiatry, Kurume University School of Medicine, Fukuoka, Japan.
Psychiatry Clin Neurosci. 1998 Apr;52(2):238-40. doi: 10.1111/j.1440-1819.1998.tb01051.x.
We investigated the circadian rhythm of hormones (cortisol, melatonin) in alcoholic patients during and 1 month after alcohol withdrawal. Patients with delirium tremens had irregular serum hormone concentration rhythms during withdrawal, which normalized after the withdrawal period. Patients without delirium tremens had normal circadian rhythms even during the withdrawal period. We speculated that the disturbance of the biological oscillator, in terms of the decline of synchronizing function or the decrease in synchronizing factors, caused abnormal circadian rhythms of hormone release during delirium tremens.
我们研究了酒精性患者在戒酒期间及戒酒1个月后激素（皮质醇、褪黑素）的昼夜节律。震颤谵妄患者在戒断期间血清激素浓度节律不规则，戒断期后恢复正常。无震颤谵妄的患者即使在戒断期间昼夜节律也正常。我们推测，就同步功能下降或同步因子减少而言，生物振荡器的紊乱导致了震颤谵妄期间激素释放的异常昼夜节律。
