Barre V, Marret S, Mendel I, Lesesve J F, Fessard C I
Neonatal Unit, Hôpital Charles Nicolle, Rouen, France.
Acta Paediatr. 1998 Apr;87(4):469-71. doi: 10.1080/08035259850157138.
A 3-d-old neonate presented with fever, hepatosplenomegaly, coagulopathy, thrombopenia and anaemia. Secondary haemophagocytic lymphohistiocytosis was suspected, as persistent cytopenias were associated with hypofibrinogenaemia, haemophagocytosis in bone marrow and decreased NK cell. There was no positive family lymphohistiocytosis history or parental consanguinity. Bacterial investigation proved negative. The diagnosis of enterovirus maternofoetal infection was carried out. The infant's condition improved with symptomatic therapy from day 7. Follow up at 1 y was normal without relapse. This is the first report of a neonatal enteroviral infection that was responsible for excessive macrophage activation.
一名3日龄新生儿出现发热、肝脾肿大、凝血功能障碍、血小板减少和贫血。由于持续性血细胞减少与低纤维蛋白原血症、骨髓噬血细胞现象及自然杀伤细胞减少有关，怀疑为继发性噬血细胞性淋巴组织细胞增生症。无家族性淋巴组织细胞增生症阳性病史或父母近亲结婚情况。细菌学检查结果为阴性。诊断为肠道病毒母婴感染。自第7天起给予对症治疗后，婴儿病情好转。1岁时随访正常，无复发。这是首例由新生儿肠道病毒感染导致巨噬细胞过度活化的报告。
