James W H
Galton Laboratory, University College London, U.K.
J Theor Biol. 1998 May 7;192(1):1-2. doi: 10.1006/jtbi.1997.0591.
The strongly male-biased sex ratios of probands with polydactyly and of their unaffected sibs suggests that abnormal maternal hormone levels may be involved in this malformation. This suspicion is supported by data relating polydactyly to maternal age and race. High maternal testosterone seems capable of explaining the (admittedly limited) epidemiological data on polydactyly. If this were so, one may predict that offspring risk would be higher in respect of affected mothers than affected fathers.
多指畸形先证者及其未患病同胞中明显的男性偏倚性性别比表明，异常的母体激素水平可能与这种畸形有关。将多指畸形与母亲年龄和种族相关的数据支持了这一怀疑。较高的母体睾酮似乎能够解释（诚然有限的）关于多指畸形的流行病学数据。如果真是这样，人们可以预测，患病母亲的后代风险会高于患病父亲的后代风险。
