钴对肝脏摄取血浆铁的影响。
The effect of cobalt on the uptake of plasma iron by the liver.
作者信息
Cunningham V J, De Matteis F, Stonard M D
出版信息
Biochem J. 1976 Jul 15;158(1):105-8. doi: 10.1042/bj1580105.
Abstract
- After an intraperitoneal injection of 59Fe the recovery of radioactivity in the liver, but not in other tissues, was increased in cobalt-pretreated rats. There was no proportional increase in the radioactivity recovered from liver haem. 2. Rats were injected intravenously with serum containing protein-bound 59Fe and 125I-labelled albumin as a marker. At various times after injection the specific radioactivities of iron in plasma and of non-haem iron in liver were determined; corrections were applied for the content of plasma in samples of liver. In cobalt-pretreated rats there was a more rapid loss of 59Fe radioactivity from the plasma and a corresponding increase in the uptake of 59Fe into liver non-haem iron. 3. The results are discussed in relation to the possible sites of action of cobalt, and the possibility is considered that only a fraction of the liver non-haem iron may be involved.
摘要
- 经腹腔注射59Fe后，钴预处理大鼠肝脏中放射性的回收率增加，但其他组织未增加。从肝脏血红素中回收的放射性没有成比例增加。2. 给大鼠静脉注射含有与蛋白质结合的59Fe和作为标记物的125I标记白蛋白的血清。注射后不同时间测定血浆中铁的比放射性和肝脏中非血红素铁的比放射性；对肝脏样品中的血浆含量进行了校正。在钴预处理的大鼠中，血浆中59Fe放射性的损失更快，并且59Fe进入肝脏非血红素铁的摄取相应增加。3. 讨论了这些结果与钴可能的作用位点的关系，并考虑了只有一部分肝脏非血红素铁可能参与的可能性。
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