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脑脊液穿刺试验在正常压力脑积水诊断中的预测价值

The predictive value of cerebrospinal fluid tap-test in normal pressure hydrocephalus.

作者信息

Damasceno B P, Carelli E F, Honorato D C, Facure J J

机构信息

Unidade de Neuropsicologia e Neurolinguistica, Faculdade de Ciências Médicas (FCM), Universidade Estadual de Campinas (UNICAMP), Brasil.

出版信息

Arq Neuropsiquiatr. 1997 Jun;55(2):179-85. doi: 10.1590/s0004-282x1997000200003.

Abstract

Eighteen patients (mean age of 66.5 years) with normal pressure hydrocephalus (NPH) underwent a ventriculo-peritoneal shunt surgery. Prior to operation a cerebrospinal fluid tap-test (CSF-TT) was performed with measurements of gait pattern and psychometric functions (memory, visuo-motor speed and visuo-constructive skills) before and after the removal of 50 ml CSF by lumbar puncture (LP). Fifteen patients improved and 3 were unchanged after surgery. Short duration of disease, gait disturbance preceding mental deterioration, wide temporal horns and small sulci on CT-scan were associated with good outcome after shunting. There was a good correlation between the results of CSF-TT and shunt surgery (chi 2 = 4.11, phi = 0.48, p < 0.05), with gait test showing highest correlation (r = 0.99, p = 0.01). In conclusion, this version of CSF-TT proved to be an effective test to predict improvement after shunting in patients with NPH.

摘要

18例正常压力脑积水(NPH)患者(平均年龄66.5岁)接受了脑室-腹腔分流手术。术前进行了脑脊液穿刺试验(CSF-TT),通过腰椎穿刺(LP)抽取50 ml脑脊液前后测量步态模式和心理测量功能(记忆、视觉运动速度和视觉构建技能)。术后15例患者病情改善,3例无变化。病程短、精神恶化前出现步态障碍、CT扫描显示颞角宽和脑沟小与分流术后良好预后相关。CSF-TT结果与分流手术之间存在良好相关性(χ2 = 4.11,φ = 0.48,p < 0.05),其中步态测试相关性最高(r = 0.99,p = 0.01)。总之,这种版本的CSF-TT被证明是预测NPH患者分流术后病情改善的有效测试。

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