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用于治疗痴呆、尿失禁和步态障碍的脑脊液分流术。

CSF shunts for dementia, incontinence, and gait disturbance.

作者信息

Black P M, Ojemann R G, Tzouras A

出版信息

Clin Neurosurg. 1985;32:632-51.

PMID:3905156
Abstract

From a review of our experience in the past 4 years and of the literature generally, the following comments can be made about selecting patients with idiopathic NPH for a shunt procedure. (a) In the clinical presentation, either significant gait difficulty or the full triad of dementia, ataxia, and incontinence should be present. If dementia occurred first or is the major symptom, shunting may not improve the patient. (b) A CT scan with periventricular low density and/or small sulci along with expansion of the entire ventricular system (especially the temporal horns) is strongly associated with good shunt outcome. However, presence of significant atrophy does not prevent shunt success if the clinical picture is appropriate. Some surgeons now feel that the clinical presentation and CT scan findings are enough in themselves to indicate a shunt. If further testing is desired, the following may be useful: Lumbar puncture: A pressure over 100 mm is associated with better chances of improvement. Improvement after lumbar puncture is associated with high likelihood of shunt success, but lack of improvement after lumbar puncture is not useful as a predictor. Isotope or metrizamide cisternography: A typical NPH pattern suggests a good response; a mixed or normal pattern is irrelevant to shunt outcome. Overnight recording of CSF pressure: If pressure is above 180 mm at night, or if there are frequent B-waves, shunting is likely to be helpful. Lumboventricular perfusion: This technique appears to give the most accurate prediction but requires special expertise and probably human studies approval to be done, as it is still an experimental procedure. These features make it difficult to use as a routine test. With regards to results of shunting once accomplished, it is important to follow patients carefully to exclude a chronic subdural collection. If a shunted patient fails to improve with persistent large ventricles and a medium or high pressure valve was used, consideration should be given to shunt revision with insertion of a lower pressure valve.

摘要

回顾我们过去4年的经验以及一般文献资料,对于选择特发性正常压力脑积水患者进行分流手术可作如下评论。(a) 在临床表现方面,要么存在明显的步态困难,要么存在痴呆、共济失调和尿失禁的完整三联征。如果痴呆首先出现或为主要症状,分流可能无法改善患者病情。(b) CT扫描显示脑室周围低密度和/或脑沟变窄以及整个脑室系统(尤其是颞角)扩大,与分流效果良好密切相关。然而,如果临床表现合适,明显萎缩的存在并不妨碍分流成功。现在一些外科医生认为,临床表现和CT扫描结果本身就足以表明需要进行分流。如果需要进一步检查,以下检查可能有用:腰椎穿刺:压力超过100mm时改善的机会更大。腰椎穿刺后病情改善与分流成功的高可能性相关,但腰椎穿刺后无改善对预测分流效果并无帮助。同位素或甲泛葡胺脑池造影:典型的正常压力脑积水模式提示反应良好;混合或正常模式与分流结果无关。脑脊液压力夜间记录:如果夜间压力高于180mm,或频繁出现B波,分流可能会有帮助。腰-脑室灌注:该技术似乎能给出最准确的预测,但需要特殊专业知识,并且可能需要人体研究批准才能进行,因为它仍是一种实验性操作。这些特点使其难以作为常规检查使用。关于分流完成后的结果,仔细随访患者以排除慢性硬膜下积液很重要。如果分流患者在使用中压或高压阀门且脑室持续扩大的情况下病情未改善,应考虑更换为低压阀门进行分流修正。

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